Kidney Disease (ie Acute Kidney Injury, Chronic Kidney Disease, Lupus Nephritis) R R R

Gut Disease (ie SIBO, Dysbiosis, Ulcerative Colitis) R R R R R RĪutoimmunity and Overall Inflammation (ie Arthritis, Autism) R RĬancer and Chemoprotection (ie EMF Exposure) R R R More importantly, if DJ-1 gets over-oxidized, NRF2 activation dies too quickly ( see post on DJ-1).

If NRF2 becomes over- or under-expressed from chronic infections/toxins (mold, lyme, EBV, metals), which can be seen in people with Chronic Inflammatory Response Syndrome (CIRS), your problems may get worse after NRF2 activation ( see more below). RĪ good example of how this works is exercise - you workout your muscle so it can adapt and can better prepared handle another workout session in the future.

This is great because NRF2 works quickly to balance redox signaling (the balance of oxidant and antioxidant levels in a cell). To break this down extremely basically: Oxidative Stress -> NRF2 -> Anti-Oxidant Response. To activate NRF2, a threshold of an oxidative response (ie inflammation) must be met so the body can create an adaptive response, and thus create antioxidants (ie glutathione). NRF2 activation decreases overall inflammation and oxidation of the body in a hormetic effect. Inactivating highly reactive metabolites and compounds (as a result of phase I) Turning them into hydrophilic (water soluble) compounds ready for excretion Phase II detoxification is paramount for taking lipophilic (fat soluble) toxins: NRF2 activity is part of the phase II detoxification system. NRF2 is paramount to keeping a healthy body as it is a master regulator of the way we handle our day-to-day environment and not get sick from everything.

System shock 2 toxin a cheat